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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Puerarin, Fluorouracil
Phytochemical Name Puerarin (PubChem CID: 5281807 )
Anticancer drug Name Fluorouracil (PubChem CID: 3385 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Decreasing Drug Toxicity
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The theory of cold and heat
Drug Name Fluorouracil
Adverse Reactions Application site erythema, application site pruritus. This was inferred hot nature anticancer drug.
Recommendations Cold: Pueraria thomsonii; Bupleurum scorzonerifolium; Pueraria thomsonii; Pueraria edulis
Reference Traditional Chinese medicine characteristics of chemotherapy regimens in advanced gastrointestinal malignant tumours[J]. Global Traditional Chinese Medicine,2023,16(8):1596-1599. DOI:10.3969/j.issn.1674-1749.2023.08.019.　　ref_link
Combination Pair ID: 413
Ref_1
Pair Name Puerarin, Fluorouracil
Disease Info [ICD-11: 2B72.Z] Gastric cancer Investigative
Gene Regulation Up-regulation Expression BAX hsa581
Down-regulation Expression BCL2 hsa596
In Vitro Model BGC-823 Human papillomavirus-related cervical adenocarcinoma Homo sapiens (Human) CVCL_3360
In Vivo Model Cells (5×10⁶ cells/mouse) were injected subcutaneously into the right dorsal area.
Result These findings showed that puerarin and 5‑FU produced a significant synergic effect on gastric cancer cells, while there was no increase in side effects.
Combination Pair ID: 412
Ref_2
Pair Name Puerarin, Fluorouracil
Disease Info [ICD-11: 2B70] Esophageal cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Up-regulation Expression CDH1 hsa999
Down-regulation Expression CDH2 hsa1000
In Vitro Model Eca-109 Esophageal squamous cell carcinoma Homo sapiens (Human) CVCL_6898
In Vivo Model A total of 24 mice were inoculated subcutaneously with injections of 1×10⁷ cells/mouse.
Result Puerarin combined with 5‑FU exhibited synergistic effects at lower concentrations and promoted apoptosis, but did not increase the side effects of chemotherapy, which indicated that puerarin may be a safe and effective chemosensitive agent in the treatment of human esophageal cancer.
03. Reference
No. Title Href
1 Synergistic antitumor effect of puerarin combined with 5-fluorouracil on gastric carcinoma. Mol Med Rep. 2015 Apr;11(4):2562-8. doi: 10.3892/mmr.2014.3016. Click
2 Synergistic effects of puerarin combined with 5-fluorouracil on esophageal cancer. Mol Med Rep. 2014 Nov;10(5):2535-41. doi: 10.3892/mmr.2014.2539. Click
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